If phenobarbital and doxycycline are administered concurrently, the clinical reaction to doxycycline really should be monitored intently.
Contraindicated (1)pentobarbital will lessen the level or outcome of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration. Strong or moderate CYP3A inducers may perhaps reduce cobimetinib systemic exposure by >eighty% and lower its efficacy.
pentobarbital will lower the extent or influence of nateglinide by influencing hepatic enzyme CYP2C9/10 metabolism. Use Warning/Observe.
pentobarbital will lessen the level or effect of isradipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.
pentobarbital decreases amounts of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Stay away from Except the coadministration outweighs the achievable risk of ponatinib underexposure; keep track of for signs of minimized efficacy.
Contraindicated (one)pentobarbital will minimize the level or outcome of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the level or effect of stiripentol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. If not able to avoid coadministration of stiripentol with potent CYP3A4 inducers, maximize stiripentol dose.
pentobarbital will decrease the level or effect of tadalafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Stay away from combination in pulmonary HTN clients. For patients with ED, keep track of reaction to tadalafil very carefully due to likely for reduced performance.
Contraindicated (1)pentobarbital will decrease the extent or outcome of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Females must not pick estradiol valerate/dienogest as their contraceptive even though utilizing solid CYP3A4 inducers on account of probable minimize in contraceptive efficacy.
Check Closely (one)pentobarbital will lower the extent or influence of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Reserve concomitant prescribing of these drugs more info in people for whom other treatment selections are insufficient. Restrict dosages and durations towards the bare minimum required. Keep an eye on carefully for indications of respiratory despair and sedation.
pentobarbital will minimize the extent or influence of ethotoin by influencing hepatic enzyme CYP2C9/ten metabolism. Use Caution/Keep track of.
pentobarbital will reduce the level or impact of cinacalcet by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will reduce the level or outcome of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.